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KMID : 1151820140080030137
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Journal of the Korean Society of Radiology
2014 Volume.8 No. 3 p.137 ~ p.145
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The Protective Effect of Red Ginseng(RG) Extracts on the Liver of Mice by X-ray Irradiation and Medication of Paraquat Orally
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Ko In-Ho
Yoe Jin-Dong
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Abstract
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The protective effects of Red Ginseng on liver damage induced by linac X-ray and paraquat were investigated. To one group of ICR male mice were given in Red Ginseng(200mg/kg/day for 7days, orally) before 5Gy(1.01Gy/min) dose of linac X-ray irradiation. To another group were given in Red Ginseng (200mg/kg/day for 7days, orally) before paraquat(30mg/kg/day, orally) was Radiation irradiation group were given with saline(0.1ml) and 5Gy. Contrast group were given with saline(0.1ml). The levels of H2O2, catalase and MDA in liver tissue were measured. In Red Ginseng to paraquat(RG+PQ) group and Red Ginseng(RG+Rad) group than irradiation group(Rad), the catalase level were significantly increased, and the catalase levels were appeared at radiation protection. The Red Ginseng was significantly decreased to MDA and H2O2 level to paraquat(RG+PQ) group and Red Ginseng(RG+Rad) group than irradiation group(Rad). Therefore, Red Ginseng was very excellent protector on radiation and paraquat of liver in mice.
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KEYWORD
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linac, x-ray, MDA, catalase, Red Ginseng, paraquat
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